Stroke is classified as a
neurological deficit attributed to an acute focal injury of the central nervous
system due to cerebral infarction, intracerebral hemorrhage and subarachnoid
Dyslipidemia is well established as
being associated with the genesis of ischemic heart disease, but has not been
conclusively demonstrated to be associated with the pathogenesis of
atherothrombotic stroke or transient ischemic attack (TIA)2. An
attempt is thus made to correlate various lipid indices including Atherogenic
Index of Plasma (AIP), Castelli Risk Index I and II (CRI-I and II), Atherogenic
Coefficient (AC), and Non-HDLc (NHC) which could be used to diagnose
individuals with elevated risks of cerebrovascular disease when the individual
parameters in the lipid profile appear normal3,4.
The prevalence of stroke in India
varies over regions, for example, ranging from 40 to 270 per 100,000 rural
population5. It is reported that more than 10% of patients with
stroke due to cerebral infarction are younger than 55 years of age. The
prevalence of standard modifiable vascular risk factors in young stroke
patients is different from that in older patients. Hypertension, heart disease
and diabetes mellitus are the most common risk factors among the elderly. On
the contrary, in young stroke patients, the most common vascular risk factors
include dyslipidemia, smoking and hypertension6. The estimated
prevalence rates increase from 0.3/1000 for below 45 years age group to
12-20/1000 in the 75-84 years age group7.
An attempt will thus
be made to compare the lipid profile and lipid indices between clinically
diagnosed young and elderly stroke patients with varying standard modifiable
vascular risk factors in the two age groups. The various lipid indices will be
calculated from the obtained data which will be further analysed statistically.
Independent “t” test will be used to compare the significant difference in the mean values between the two groups.