Introduction calculate glomerular filtration rate (eGFR) on the


disease constitutes the recurrent dominant cause of universal death affecting
the youthful society. (1) The clinical entity
silent MI annually experience CHD with the approximate 9.8 million every year
predicting the unrecognized symptoms related with the phenomenon of either
ambulatory ischemic events or unexpected death on 70%-80%  asymptomatic manifestation.(2) The kidney disease predictions on clinical
practice guidelines proves the demonstration of ischemic chest pain is a strong
venue of cardiovascular morbidity measures and all cause-mortality (3)  with classifications
of hemo- dynamic alterations independently calculate glomerular filtration rate
(eGFR) on the scheme of  arbitrary renal
staging in altering albuminuria,  hyperfiltration and hyperglycemia in renal
failure. Consequently CKD as a clinical syndrome equivalent to CHD investigate
the urinary excretion proteins and TGF-beta 1 initially in nephropathy as a
diagnostic value in clinical parameters of previous MI in diabetic individuals. (4)

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In the
Framingham heart study, the estimation of silent ischemia detection on large
scale misinterpret by atypical angina following normal ECG with the
unnoticeable prevalence in broad ranging population 300mg/day. Thus, the supportive directions on definite
limitations of safety concerns utilize the consideration of Renin Angiotensin
Aldosteron System (RAAS) lessens micoalbuminuria 30-300mg/day in normic
diabetes cases. (12)


as a therapeutic potent in diabetes, the epidemiological early analysis
illustrate the fundamental controversy of minimal outcomes in macrovascular
hazards can ascend the occasion of CVD risk factors, extravagant mortality
rates and vigorous symptoms with the median of HbA1c%. The Action in Controlling
Cardiac Risk factors in Diabetes (ACCORD) present the current affirmation of
delaying vascular complications related to the consequences of CKD staging 3-4
can be patently achieved by the optimal goal of HbA1c and hypoglycemia
incidents. Accordingly, a tight control on hyperglycemia is permeable to
convert the high risk of hyperfiltration and glomerular hypertrophy partially
on HbA1c