Drug inherent cytotoxiciity. Dendrimers were found to

Drug can either entrapped within voids of dendrimer or drug
can be used as a dendrimeric scaffold or covalently attached to dendrimer
surface. Drug loading  capacity of
dendrimer is lower as compared to other carriers, however, covalently generated dendritic
molecules exhibit much controlled and 
specific drug release and hence can be designed for sustained controlled
drug release in the systemic circulation as well as triggered release under
specific physiological condition e.g. tumour specific .
They are unique in architecture having uniform in shape, size and molecular
weight and transdermal permeability depends on molecular weight, generation
size, charge on surface, composition and concentration. Dendrimers show better penetration due to
their ability to interact with lipids present in cell membranes. Hence they act
as solubility enhancers and permeation enhancers of lipophilic drugs. However,
they cannot be good carriers for hydrophilic drugs. Main advantage of using dendramers is
their multivalency.  Major drawbacks of
dendrimers as transdermal carriers are their poor biodegradatin profile and
inherent cytotoxiciity. Dendrimers were found to be good penetration
enhancer in TDDS for many drugs.  Polyhydroxyalkanoates (PHA)
with Poly(amidoamine) (PAMAM) dendrimer were found to be diffusion enhance
of tamsulosin by varying the
macroscopic constitution of water in the solution. Chauhan et al. (2003) investigated
three different PAMAM (G4.0-NH2, G4.0-OH, and
G4.5 PAMAM) dendrimers for transdermal drug delivery indomethacin and found
that amine terminated dendrimers lead to enhanced solubility due to
electrostatic interactions of the carboxyl group of the drug with the amino
groups of the dendrimer.   G5 PAMAM dendrimer was also investigated for
its ability of enhanced permeation of nonsteroidal anti-inflammatory drugs ketoprofen and diflunisal, 3.4 times higher
permeation of ketoprofen and 3.2 times of diflunisal was found in in vitro studies on rat skin. Similarly, anti-nociceptive studies was also exhibited
prolonged pharmacodynamic profile and higher bioavailability for the
NSAIDs-PAMAM dendrimer complex as compared to pure drug suspensions.

Jose and Charyulu (2016) used polyamidoamine (PAMAM) dendrimer for effective
delivery of potent antifungal agent amphotericin B (AmB) (poor water
solubility). They reported that with increase in PAMAM dendrimer generation and
concentration the solubility of AmB increases many fold and AmB binding into
dendrimers led to sustained release of  in vitro . PAMAM dendrimer complex also emerged as promising candidate as
drug carrier vehicle for fluorouracil
 and peptides.

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Dendrimer
find application in transport photosensitizers (PS) for photochemical therapy
and antifungal molecules. Rodriguez et al (2015) studied the
aminolevulinic acid (ALA) dendrimers
6 and
9 ALA residues carrying
ability to photosensitise cancer cells. It was observed that when it was applied
on skin overlying a subcutaneous LM3 implanted tumour, no diffusion of the
molecules was seen either to distant sites or to the adjacent tumour.  Study suggested that ALA dendrimers  is a promising molecules in PDT in treating
superficial cancer as well as in vascular PDT for the treatment of
atherosclerosis.