Cardiovascular to be driven by various mechanisms: apart

Cardiovascular disease (CVD) is a
class of diseases that involve the heart or blood vessels.
Cardiovascular disease includes coronary artery disease (CAD)
such as angina  and myocardial infarction (commonly known
as a heart attack).1

diseases account for more deaths worldwide than any other disease. Together they
resulted in 17.9 million deaths (32.1%) in 2015, up from 12.3 million (25.8%)
in 1990.2

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Overweight and obesity are major risk
factors for a number of chronic diseases, including cardiovascular diseases.
other risk factors includes hypertension, dyslipidaemia and impaired glucose
tolerance/insulin resistance.3

Vitamin D is a fat-soluble vitamin that functions as
a steroid hormone.  it has been recognized
as a vitamin which is essential for bone–mineral health. numerous experimental
and observational studies have highlighted the role of vitamin D in immunity,
metabolic syndrome (obesity and diabetes), cancers, renal disease, memory, and
neurological dysfunction.4

recent studies have suggested a potential role of 25-hydroxyvitamin D
(25-OH-D), the major circulating form of vitamin D, in risk reduction of
cardiovascular diseases (CVD) 5

Although the
underlying biological causes are not fully understood, the association of
25-OH-D with cardiovascular pathology is speculated to be driven by various
mechanisms: apart from a potential direct impact on cardiomyocytes and
myocardial diseases, it has been suggested that 25-OH-D indirectly modifies CVD
risk by its association with cardiovascularrisk factors like obesity, diabetes,
hypertension, smoking, or cholesterol level.

However, vitamin D physiology may differ according
to body weight. individuals with obesity require higher doses of vitamin D in
order to improve their vitamin D status compared to subjects with normal weight

Association between vitamin D status  and cardiometabolic profile improvement in
adults with obesity will be useful public 
health initiatives in using vitamin D supplementation to improve
cardiovascular risk in adults with obesity.